• Sleep Apnea

    How can you tell if you have Sleep Apnea? Ask your spouse, family, or those around you. Here are some questions to ask: 1. Are you a loud, habitual snorer, disturbing your companion? 2. Do you feel tired and groggy in the morning? 3. Do you experience sleepiness and fatigue during the day? 4. Are you overweight? 5. Have you been observed to choke, gasp, or hold your breath during sleep? If you answered yes to one or more of these questions, you should discuss your symptoms with your physician. Blood oxygen saturation is reduced in the entire body during apnea -- sometimes producing serious irregular heartbeats and significantly reduced oxygen to the brain. Common symptoms of Sleep Apnea are a decreased ability to concentrate; loss of energy and/or fatigue; mild to marked depression; irritability; short temper; morning headaches; forgetfulness; anxiety; and, most frequently, excessive daytime sleepiness. Read More
  • Narcolepsy

    Narcolepsy, and related disorders, is typified by the inability to stay awake. Narcoleptics may suddenly fall asleep while they are engaged in an activity (for example, while waiting for a traffic light to change). Attacks are occasionally brought on by laughing, crying, and other strong emotions in a group setting. This illness often goes undiagnosed for years. Read More
  • Insomnia

    Insomnia is an inability to fall asleep or stay asleep. Attacks are often brought on by stress; worry; depression; another illness; persistent pain; and sleeping pill habits. Evaluating insomnia is important even if the condition seems temporary. Read More
  • Other Sleep Disorders

    Some people suffer from nightmares, night terrors, sleep walking, excessive body jerks, or uncontrollable leg movements. These people often get less than four and one-half hours of restorative sleep -something our bodies need. Even though a person spends ten hours in bed, they may only get two hours of restorative sleep. It is important to have your sleep analyzed if you find yourself waking up more tired than when you went to bed. Read More
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Polyinosinic-Polycytidylic Acid Poly-L-lysine (PolylCLC)

Polyinosinic-Polycytidylic Acid Poly-L-lysine (PolylCLC): A New Anti-Dysimmune Effect Remarkably Beneficial in Neuropathies


We introduced PolylCLC (stablized with carboxymethyl cellulose) as a new treatment for dysimmune dysschwannian neuropathy (DSN) in one patient (Lancet 1:503, 1978). Off all other drugs for more than 1.5 years, he continues after 3 years to benefit and be dependent upon PolylCLC. Now age 31, he has had motor DSN from age 15, and eventually was refractory to prednisone, azathioprine, and plasmapheresis. Confined to an electric wheelchair and hardly able to use his limbs before PolylCLC, now, at the peaks of PolylCLC action, he is normal proximally and much improved distally, and can walk 8 miles a day. Four of seven other motor-sensory DSN and two of two dysimmune dysneuronal motor-sensory neuropathy patients refractory to other drugs now have beneficial responses extending over 1-2 years, allowing elimination or major reduction of any other medications. Each IV dose (20-100 ng/kg) of PolylCLC causes benefit lasting 2-6 weeks. Acutely, there is 4-18 hours flu-like syndrome, 4-5 days selective lymphocyto-penia to 1-20 percent of baseline, 24-48 hours granulocytosis 2-3 x baseline, 48 hours hypercorticoidemia, and minimal < 24 hours hyperinterferonemia. The beneficial effect of Poly-IULC is unlikely to be simply glucocorticoid because responsive patients had severe prednisone side effects at the beginning of treatment, which dissipated as prednisone was withdrawn.

- April 1981 Neurology (Ny) 31 (2) Page 154